Acquired Tlymphocyte abnormalities

Reduced numbers

• HIV infection (see following pages).

• Purine analogues especially fludarabine and cladribine.

• Deoxycoformycin (adenosine deaminase inhibitor).

• After allogeneic stem cell transplantation.

Reduced function: Lymphoproliferative disorders, Hodgkin's disease, immunosuppressive agents e.g. cyclosporin and steroids, burns, uraemia.

Clinical features: Increased risk of viral, fungal and atypical infections including HSV, HZV, CMV, EBV, Candida, Aspergillus, Mycoplasma, PCP, toxoplasmosis, TB and atypical mycobacteria.

Treatment: Treat specific infection where possible. Consider prophylaxis against HZV, CMV, PCP and Candida in high risk groups e.g. post-allogeneic stem cell transplant.

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