Abo

haemolytic disease of the newborn 441

incompatibility 316-17 abortion, recurrent 401 acanthocytosis 114

hereditary 97 acquired conditions 114

-immune haemolytic syndromes 68, 69

megaloblastic anaemia 64 neutrophil function disorders 464 -non-immune haemolytic syndromes 68, 69 activated protein C resistance 396 acute lymphoblastic leukaemia 158-63, 576 aetiology 158 -allo and autografts 310 clinical features 159 cytogenetic analysis 159 emergency treatment 161 immunological classification 158 immunophenotyping 158 incidence 158

investigations and diagnosis 159-60 minimal residual disease detection 162

prognosis/prognostic factors 162, 163

relapse management 163 specific treatment 161-2 supportive treatment 161 acute myeloblastic leukaemia (AML) 150 -7 aetiology 150

biphenotypic leukaemias 153 clinical features 154-5 cytochemistry 151 cytogenetic analysis 153-4 diagnosis 150 emergency treatment 155 immunophenotyping 152 incidence 150

lineage infidelity 153 molecular analysis 154 prognosis 157 prognostic factors 157 relapse management 157 specific treatment 156-7 supportive treatment 155 World Health Organisation classification 151-2 addresses 664-9

adenosine deaminase deficiency 408-9 adrenal disorders 48 adriamycin 594, 596, 620, 622, 624 (doxorubicin), BCNU (carmustine) cyclophosphamide, melphalan (ABCM) 278, 620 (doxorubicin), bleomycin, vinblastine, dacarbazine (ABVD) 596, 602 aggregants 370 albumin 425 alkalinisation 560 allergic reactions 585 allogeneic transplants 336 allografts 337

alloimmune thrombocytopenia, neonatal 448-9 allopurinol 258, 560 amniotic fluid 442 amphotericin 330 amyloidosis (primary systemic) 32,

288-91 anaemia 278, 456-7 aplastic 122-3

autoimmune haemolytic 116-17 of chronic disorders 50-1 congenital dyserythropoietic 450-1 dilutional 34 drug related 52 drug-induced haemolytic 108 in endocrine disease 48 in gastrointestinal disease 52 haemolytic of the neonate 434 hereditary 130 iron deficiency 56-8 in joint disease 50-1 large bowel 52 leucoerythroblastic 120

anaemia (continued) in liver disease 54 megaloblastic 64 microangiopathic haemolytic

(MAHA) 112, 438 neonatal 430-1 oesophageal 52 pancreas 52

and peripheral blood film 44 pernicious 60 in pregnancy 34 of prematurity 432 pure sideroblastic 228 refractory 220, 486 in renal disease 46 sickle cell 72 small bowel 52 unexplained 10-11 anagrelide 244, 252 analgesics 258, 538-9, 569, 585

simple non-opioid 538 aniline dyes 496 ankylostoma 495 Ann Arbor stating classification

(Cotswolds modification) 210, 213

antenatal diagnosis 355 anti-arrhythmics 585 antibacterial prophylaxis 550 antibiotics intravenous 552-3 prophylactic 569 antibodies 69, 441

antiplatelet 378, 380 anticoagulation 402 acquired 366-8 heparin 588-9 lupus 400 oral 590

post-partum 404-5 prophylactic 401, 588-9 therapeutic 588 anti-D prophylaxis 390, 441 antidepressants 585 antiemetics 574, 574-5 antiepileptics 585 antifungal prophylaxis 550 therapy 330-2 anti-infective therapy 230 anti-inflammatory drugs 538 antiphospholipid syndrome 401

antiplatelet antibodies 378, 380 antithrombin concentrate 398 III deficiency 397 antiviral prophylaxis 550 therapy 418 apheresis 584 aplasia acquired red cell 454-5 congenital red cell 452-3 pure red cell 126 aplastic crises 73 argatroban 521 arthropathy, chronic 353 aspirin 244, 253, 378-9 ataxia telangiectasia 410 atypical organisms 556 autohaemolysis test 98 autoimmune disorders 32, 582 azacytidine 76 azo compounds 496

B cells 408, 410 B lineage 158 babesiosis 96 bacteriology 302, 544 basopenia 142 basophilia 142

BEAM (BCNU, etoposide, cytarabine (ara-C), melphalan) 610, 612-13 benzodiazepines 574, 585 beta blockers 585 bilirubin 320

biochemistry 302, 471, 544, 689 bird-headed dwarfism 460 Birmingham Clinical Trials Unit 668 bisphosphonates 279 bleeding 51, 360-1, 588 active 365 disorders 344 neonate 448-9 prolonged after surgery 38-9 vWF-related 348-50 see also haemorrhage bleomycin 594, 596, 602 blind loop syndromes 61

blood basophilia, peripheral 142 cells 496

coagulation network 347 component therapy 424-6 count in children 422-3 full 10-11, 632, 690 values, normal 423 disorders, malignant 470-2 film 168, 632

leucoerythroblastic 14 peripheral 44 group 546, 644 loss 34, 56

see also bleeding; menstrual loss lymphocytes, peripheral 138 monocytes, peripheral 144 products, bacterial contamination of 506

products, issue and administration of 644

salvage, intraoperative 658 saving, pharmacological methods of

659 source of 424 tests 340

transfusion 258, 644-61 autologous 658-9 cryoprecipitate 654 fresh frozen plasma 652-3 immunoglobulin, intravenous 656-7

Jehovah's Witnesses 660-1 laboratory 644 massive 524-5 maximum surgical blood ordering schedule 646 platelets 650 red blood cells 648-9 B-lymphocyte abnormalities 413 body surface area nomogram 682 bone 4 disease 277 marrow 120, 169 examination 570-1 failure, chronic 562-3 harvesting 304-5 transplant 76, 302-3 tumours 470 brain tumours 470

British Society for Haematology 669 bruising, easy 24-5 Bruton tyrosine kinase deficiency 410

C-Thal-Dex 628

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