• Pathophysiology: idiopathic granulomatous vasculitis of upper and lower respiratory tract with glomerulonephritis (may be autoimmune)
• Types: limited (no renal involvement), systemic (pulmonary and renal involvement)
• Histopathology: necrotizing granulomas (with multinucleated giant cells) with vasculitis of upper and lower respiratory tract
• Rx: corticosteroids for initial control followed by cyclophosphamide, azathioprine, or methotrexate; may consider prophylaxis trimethroprim-sulfamethoxazole; nasal hypertonic saline irrigations and nasal debridement for local therapy
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