Wfegeners Granulomatosis

• Pathophysiology: idiopathic granulomatous vasculitis of upper and lower respiratory tract with glomerulonephritis (may be autoimmune)

• Types: limited (no renal involvement), systemic (pulmonary and renal involvement)

• Histopathology: necrotizing granulomas (with multinucleated giant cells) with vasculitis of upper and lower respiratory tract

• Rx: corticosteroids for initial control followed by cyclophosphamide, azathioprine, or methotrexate; may consider prophylaxis trimethroprim-sulfamethoxazole; nasal hypertonic saline irrigations and nasal debridement for local therapy

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