Bullous Pemphigoid

• Pathophysiology: autoantibodies results in subepidermal blistering

• similar to Cicatrical Pemphigoid, however Bullous Pemphigoid has cutaneous lesions (rare oral lesions), self limiting, affects both genders, and is positive for serum indirect immunofluorescence

• SSx: subepithelial bullae of flexor surfaces, groin, and abdomen; self limiting; rare oral lesions, seen in 7th—8th decade

• Dx: direct immunofluorescence of basement membrane (subepithelial clefting), positive serum indirect immunofluorescence (70%)

• Rx: oral corticosteroids, may consider immunosuppressive agents

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