Factors that affect survival in patients with metastasis from an unknown primary tumour are clinical stage of the neck, extranodal extension of metastasis and the presence of recurrent or residual disease after treatment. Surgery combined with irradiation has resulted in better local control of the disease than either therapy alone . The 5-year survival results in series of patients with SCC metastatic to the neck from an unknown primary origin range from 0 to 54% [45, 64, 72, 75]. In the last series from the University of Texas M.D. Anderson Cancer Center, the 5-year actuarial survival rate was 55% .
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