TNM Grading

For the staging of laryngeal cancer, the TNM system (T - tumour, N - node, M - metastasis), established by the International Union Against Cancer (UICC) is widely used [340]. Stage remains the most significant predictor of survival. The size of the tumour and the presence of regional and distant metastases are independent predictors of survival.

An important parameter ignored in the TNM system is extracapsular spread. Several studies have shown that the presence of extracapsular spread in the lymph nodes is strongly associated with both regional recurrence and distant metastases, resulting in decreased survival [71, 116, 157, 344]. Some studies, on the contrary, have not confirmed the independent prognostic significance of extracapsular spread [225, 292].

Mole Removal

Mole Removal

Moles, warts, and other unsightly irregularities of the skin can be bothersome and even embarrassing. They can be removed naturally... Removing Warts and Moles Naturally! If you have moles, warts, and other skin irregularities that you cannot cover up affecting the way you look, you can have them removed. Doctors can be extremely expensive. Learn the natural ways you can remove these irregularities in the comfort of your own home.

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