Osteopetrosis

Osteopetrosis (often known as marble bone disease) is a rare disease of bone, in which there is a failure to absorb calcified cartilage and primitive bone due to deficient activity of osteoclasts. A relatively benign form, inherited as a dominant, presents in adults, and a malignant one, inherited as a recessive, in infants and young children. The patients with the benign form often survive to old age and present prominent otological symptoms. The intermediate, endochondral portion of the otic capsule is swollen and appears as an exaggeratedly thickened form of the normal state. Globuli ossei composed of groups of calcified cartilage cells are normally present in this region, and in osteopetrosis they are greatly increased in number and are arranged into a markedly thickened zone. The periosteal bone is normal. The ossicles are of foetal shape and filled with unabsorbed, calcified cartilage. The canals for the sev-

Fig. 8.19. Cytomegalovirus infection of vestibular nerve in the region of Scarpa's ganglion. The nerve is inflamed with the infiltration of neutrophils, leucocytes and plasma cells. Four enlarged cells, three to the left of centre, the fourth on the far right) with purplish inclusions, each surrounded by a pale halo, features characteristic of cytomegalovirus infection, can be identified. Autopsy findings in a patient with AIDS. Reproduced from Michaels and Hellquist [68]

Fig. 8.19. Cytomegalovirus infection of vestibular nerve in the region of Scarpa's ganglion. The nerve is inflamed with the infiltration of neutrophils, leucocytes and plasma cells. Four enlarged cells, three to the left of centre, the fourth on the far right) with purplish inclusions, each surrounded by a pale halo, features characteristic of cytomegalovirus infection, can be identified. Autopsy findings in a patient with AIDS. Reproduced from Michaels and Hellquist [68]

enth and eighth cranial nerves are greatly narrowed by the expanded cartilaginous and bony tissue and these changes are probably responsible for the characteristic symptoms of facial palsy and hearing loss respectively [36, 74, 77].

Was this article helpful?

0 0
Mole Removal

Mole Removal

Moles, warts, and other unsightly irregularities of the skin can be bothersome and even embarrassing. They can be removed naturally... Removing Warts and Moles Naturally! If you have moles, warts, and other skin irregularities that you cannot cover up affecting the way you look, you can have them removed. Doctors can be extremely expensive. Learn the natural ways you can remove these irregularities in the comfort of your own home.

Get My Free Ebook


Post a comment