Pv of uniform, small, undifferentiated, primitive neuro-ectodermal cells (Fig. 2.13a) . The great majority of these tumours will react strongly with antibodies against the MIC-2 (CD99) protein product (Fig. 2.13b). This marker is of considerable value, but it is by no means specific. A growing number of other neoplasms expressing this protein have been documented. Among these are T-cell lymphomas . The standard translocation t(11; 22) (q24; q12) of PNET  results in the fusion of the EWS-FLI1 genes. The detection of the chimeric transcript by techniques of molecular biology confirms the diagnosis . We have seen one example of PNET arising from the maxillary antrum , which ultrastructurally showed rudimentary neuritic differentiation, as well as scanty microtubule formation. This raised the differential diagnostic dilemma of "ectopic olfactory neuroblastoma"; nevertheless, the tumour cells were positive for MIC-2 and showed the t(11;22)(q24;q12) translocation, findings that are characteristically negative in ONB .
metastases account for the rest . Distant metastases mainly involve bone and lung . Complete surgical excision, often followed by radiation therapy and/or chemotherapy, seems to be the treatment of choice [14, 179]. In advanced ONB, high-dose chemotherapy and autologous bone marrow transplantation has been used [68, 188].
Was this article helpful?
Moles, warts, and other unsightly irregularities of the skin can be bothersome and even embarrassing. They can be removed naturally... Removing Warts and Moles Naturally! If you have moles, warts, and other skin irregularities that you cannot cover up affecting the way you look, you can have them removed. Doctors can be extremely expensive. Learn the natural ways you can remove these irregularities in the comfort of your own home.