Myospherulosis is characterised by the presence of cystlike spaces lined by flattened histiocytes and containing clusters of brownish spherules resembling fungi [198, 217, 230]. They lie loosely or within sacs formed by thin refractile membranes. The brownish spherules do not stain with PAS or Gomori methanamine silver and their morphology does not correspond to any known fungus [228]. They are found within fibrous granulation tissue, which may show a foreign body reaction. The lesion is usually found in patients who have had previous operations [145]. It is now recognised that the spherules are extravasated red cells that have been altered by interaction with traumatised fat or petrolatum-based ointments and gauzes used in surgical procedures.

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