Mucoepidermoid Carcinoma

ICD-O:8430/3

Mucoepidermoid carcinoma (MEC) occurs at all ages, even in childhood, but it usually presents in the 6th and 7th decades, predominantly in males. The majority occurs in the supraglottis, but it has also been described in the glottis and subglottis, as well as in the hypopharynx [221, 335]. The clinical picture correlates with the localisation and size of the tumour.

Fig. 7.14. Chondrosarcoma of the cricoid cartilage of the larynx. a Typical macroscopic appearance of the tumour located in the cricoid cartilage: cut section reveals a glistening, lobulated, glassy tumour. b Microscopically, there is slightly increased cellularity, binucleation in the lacunar spaces, mild nuclear pleomorphism and hyperchromasia

Fig. 7.14. Chondrosarcoma of the cricoid cartilage of the larynx. a Typical macroscopic appearance of the tumour located in the cricoid cartilage: cut section reveals a glistening, lobulated, glassy tumour. b Microscopically, there is slightly increased cellularity, binucleation in the lacunar spaces, mild nuclear pleomorphism and hyperchromasia

Macroscopically, they mostly present as submucosal masses [335].

Microscopically, they are similar to MEC in other sites, and are classified as low-, intermediate-, and highgrade MEC (see Chap. 5).

The behaviour is unpredictable, and is related to the grade and stage of the disease. The best treatment is complete surgical excision. Radiotherapy has been reported to be successful in a limited number of patients [335]. Neck dissection may be necessary, as 50% of patients with MEC have metastases in the regional lymph nodes. The 5-year survival is 90-100% for low-grade MEC, and 50% for high-grade MEC [115].

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