Ml

c d

Fig. 6.5. Non-keratinizing nasopharyngeal carcinoma. a-b Na- tinizing nasopharyngeal carcinoma can be heavily infiltrated by sopharyngeal carcinoma grows in solid sheets of large epithelial the lymphocytes. f Tumour cells are large, undifferentiated, with cells which are clearly demarcated by a mixed inflammatory in- abundant pale cytoplasms, inconspicuous cell membranes, and filtrate consisting of lymphocytes, plasma cells and histiocytes. large nuclei with prominent nucleoli c globular amyloid deposition is not uncommon. d-e Non-kera-

Fig. 6.5. Non-keratinizing nasopharyngeal carcinoma. a-b Na- tinizing nasopharyngeal carcinoma can be heavily infiltrated by sopharyngeal carcinoma grows in solid sheets of large epithelial the lymphocytes. f Tumour cells are large, undifferentiated, with cells which are clearly demarcated by a mixed inflammatory in- abundant pale cytoplasms, inconspicuous cell membranes, and filtrate consisting of lymphocytes, plasma cells and histiocytes. large nuclei with prominent nucleoli c globular amyloid deposition is not uncommon. d-e Non-kera-

may be present. Small amyloid globules can be found within the tumour cells or scattered among the carci-nomatous stroma. Epithelioid granulomas, occasionally with caseous necrosis, have been described in nasopharyngeal carcinoma in up to 18% of cases. Some fea tures are associated with a better prognosis of nasopharyngeal carcinoma: high density of dendritic cells, high number of infiltrating lymphocytes, and low numbers of granzyme-B positive cytotoxic cells [58, 80, 151, 208]. The most reliable and sensitive method of detection of

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