Malignant Peripheral Nerve Sheath Tumour

The Peripheral Neuropathy Solution

Neuropathy Solution Program

Get Instant Access


Malignant peripheral nerve sheath tumour (MPNST) of the sinonasal tract is a very rare neoplasm [163] that is probably under-recognised due to the lack of reproducible histologic criteria and to the tendency of these tumours to be negative for the commonly used immuno-histochemical markers of nerve sheath differentiation. Only in some cases can the diagnosis be based on the identification of a pre-existing neurofibroma. Histologically, MPNST is a moderately to highly cellular spindle cell proliferation, with variable mitotic activity and areas of necrosis. A variant composed of epithelioid cells has been described in the sinonasal cavities (Fig. 2.18) [76]. Some tumours may show morphologic and immuno-histochemical features of skeletal muscle differentiation and are designated "malignant triton tumours" [138].

Was this article helpful?

0 0
Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook

Post a comment