The majority of conjunctival melanomas arise within primary acquired melanosis with atypia. Development of a melanoma in a pre-existing naevus or de novo is possible, but uncommon [44, 61]. In malignant melanoma clusters of atypical melanocytes are present in the stroma (Figs. 10.14, 10.15). The melanocytes are most frequently epithelioid, but can also be spindle-shaped or bizarre. The intraepithelial component shows large, atypical melanocytes, often without ascending cells. This differs from skin melanocytic lesions, where ascending melanocytes can be very helpful in diagnosing a malignant melanoma. These cytological characteristics do not seem to influence prognosis. Depth of the tumour, however, does have prognostic value: thickness less than 1.5 mm means a low risk of metastatic disease.
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.