Lens Induced Uveitis

Lens-induced uveitis or phacoanaphylactic endophthalmitis is a chronic endophthalmitis with a zonal granulomatous inflammation surrounding a ruptured lens. Most cases occur after trauma, surgical or non-surgical. The condition may result in vision-threatening intraocular inflammation that is poorly responsive to medical management. Leaking of lens proteins through an intact lens capsule may result in a lympho-plasmacytic anterior uveitis [102, 127]. The inflammation can be confined to the anterior aspect of the eye, but the choroid can also be involved. Surgical removal of the lens material is generally indicated shortly after the injury in an effort to save vision. Normally, small amounts of circulating lens proteins maintain a normal T-cell tolerance for lens proteins. Lens-induced uveitis develops when a breakdown occurs of this normal T-cell tolerance. Immune complexes play an important role in the tissue damage associated with the ensuing inflammation.

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