Laugier Hunziker Syndrome

Laugier Hunziker syndrome is an acquired, benign macular hyperpigmentation of the lips and oral mucosa [118]. It typically starts in early to middle adult life and is more common in women than men. The pigmentation consists of brownish, circular or linear macules, that may be sharply circumscribed or more diffuse in nature, and lesions may coalesce. The lesions are seen most commonly on the buccal mucosa, lips and the hard and soft palates. Other less frequent sites include the tongue, gingiva and floor of the mouth. Occasionally, the pharynx and oesophagus are also involved [190]. About half of the cases also have nail involvement in the form of longitudinal pigmented bands in one or more fingers or toes. There are no known systemic associations.

Microscopy shows increased melanotic pigmentation of basal keratinocytes and melanophages in the superficial corium secondary to pigmentary incontinence. Ultrastructural studies show increased numbers of normal-appearing melanosomes in keratinocytes in the lower epithelial layers [118].

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