Invasive Squamous Cell Carcinoma

ICD-O:8070/3

Squamous cell carcinoma (SCC) is by far the most common malignant tumour of the larynx and hypopharynx, accounting for about 95-96% of all malignant tumours at this location. The majority are conventional-type SCC.

cancer, but the results are conflicting. HPV, mainly type 16, has been found in 3-85% of laryngeal cancers [213]. Moreover, HPV DNA has been detected in 12-25% of individuals with a clinically and histologically normal larynx [271, 313]. It appears, therefore, that HPV infection plays little role, if any, in laryngeal carcinogenesis [126, 177, 211, 213].

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