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Contents

5.1 Introduction 132

5.1.1 Normal Salivary Glands 132

5.1.2 Developmental Disorders 132

5.2 Obstructive Disorders 132

5.2.1 Mucus Escape Reaction 132

5.2.2 Chronic Sclerosing Sialadenitis of the Submandibular Gland (K├╝ttner Tumour) . . . 133

5.3. Infections 133

5.3.1 Bacteria, Fungi 133

5.3.2 Viruses 133

5.4 Miscellaneous Inflammatory Disorders 133

5.5 Miscellaneous Non-Inflammatory Disorders 133

5.5.1 Necrotising Sialometaplasia

(Salivary Gland Infarction) 133

5.5.2 Sialadenosis 133

5.5.3 Adenomatoid Hyperplasia of Mucous Salivary Glands 134

5.5.4 Irradiation Changes 134

5.5.5 Tissue Changes

Following Fine Needle Aspiration 134

5.6 Oncocytic Lesions 134

5.6.1 Focal and Diffuse Oncocytosis 134

5.6.2 Ductal Oncocytosis 134

5.6.3 Multifocal Nodular Oncocytic Hyperplasia 135

5.7 Cysts 135

5.7.1 Salivary Polycystic Dysgenetic Disease 135

5.7.2 Mucoceles 135

5.7.3 Simple Salivary Duct Cysts 135

5.7.4 Lymphoepithelial Cystic Lesions 135

5.7.4.1 Benign Lymphoepithelial Cyst 135

5.7.4.2 Cystic Lymphoid Hyperplasia of AIDS 136

5.7.5 Sclerosing Polycystic Sialadenopathy

(Sclerosing Polycystic Adenosis) 136

5.7.6 Other Cysts 137

5.8 Benign Tumours 137

5.8.1 Pleomorphic Adenoma 137

5.8.1.1 Salivary Gland Anlage Tumour

("Congenital Pleomorphic Adenoma") 140

5.8.2 Benign Myoepithelioma 140

5.8.3 Basal Cell Adenoma 141

5.8.4 Warthin's Tumour 142

5.8.5 Oncocytoma 143

5.8.6 Canalicular Adenoma 143

5.8.7 Sebaceous Adenoma 144

5.8.8 Sebaceous Lymphadenoma 144

5.8.9 Ductal Papilloma 144

5.8.10 Cystadenoma 144

5.9 Malignant Epithelial Tumours 144

5.9.1 Acinic Cell Carcinoma 144

5.9.2 Mucoepidermoid Carcinoma 146

5.9.3 Adenoid Cystic Carcinoma 147

5.9.4 Polymorphous Low-Grade Adenocarcinoma 148

5.9.4.1 Cribriform Adenocarcinoma of the Tongue 149

5.9.5 Epithelial-Myoepithelial Carcinoma 150

5.9.6 Hyalinising Clear Cell Carcinoma 151

5.9.7 Basal Cell Adenocarcinoma 151

5.9.8 Myoepithelial Carcinoma

(Malignant Myoepithelioma) 152

5.9.9 Salivary Duct Carcinoma 154

5.9.10 Oncocytic Carcinoma 155

5.9.11 Malignancy in Pleomorphic Adenoma

Malignant Mixed Tumour 156

5.9.11.1 Carcinoma (True Malignant Mixed Tumour)

Ex Pleomorphic Adenoma 156

5.9.11.2 Carcinosarcoma Ex Pleomorphic Adenoma 157

5.9.11.3 Metastasising Pleomorphic Adenoma 157

5.9.12 Sebaceous Carcinoma 158

5.9.13 Lymphoepithelial Carcinoma 158

5.9.14 Small Cell Carcinoma 158

5.9.15 Higher Grade Change in Carcinomas 159

5.9.16 Metastatic Malignancies 159

5.10 Hybrid Carcinoma 160

5.11 Endodermal Sinus Tumour 160

5.12 Sialoblastoma 160

5.13 Alterations in Gene Expression and Molecular Derangements in Salivary Gland Carcinoma 160

5.13.1 Predominantly Myoepithelial Malignancies 161

5.13.2 Predominantly Epithelial Malignancies 161

5.14 Benign and Malignant Lymphoid Infiltrates 162

5.14.1 Non-Autoimmune Lymphoid Infiltrates 162

5.14.2 Benign Autoimmune Lymphoid Infiltrates 162

5.14.3 Malignant Lymphoma 163

5.15 Other Tumours 163

5.16 Unclassified Tumours 163

References 164

5.1 Introduction

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