The most important causes of infectious granulomatous inflammatory diseases of the intraocular tissues are tuberculosis and toxoplasmosis.
Tuberculosis is rare and shows caseating granulomas, in which tubercle bacilli can be found in a Ziehl-Neelsen staining.
Toxoplasmic retinochoroiditis in neonates infected in utero with Toxoplasma gondii can show a wide variation in the pattern of tissue destruction. The disease can be limited to a low grade uveitis and retinal lymphocytic perivasculitis. In more severely affected eyes focal, sectorial or total retinal destruction can be seen. Toxoplas-ma cysts can be found in the retina and optic nerve. In the most severely affected eyes the retina is necrotic and calcified .
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