Histological Classifications

3. Severe dysplasia: architectural disturbance is greater than two-thirds of the epithelium with associated cytological atypia or architectural disturbance in the middle third of the epithelium with sufficient cyto-logical atypia to upgrade from moderate to severe dysplasia.

C. Carcinoma in situ: full or almost full thickness of the epithelium shows architectural disturbance, accompanied by pronounced cytological atypia. Atypical mitotic figures and abnormal superficial mitoses are present [381].

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