Heterotopic Brain Tissue

This lesion mostly occurs in young children, usually the result of a congenital abnormality related to a variant of meningoencephalocele [136, 196]. Commonly used synonyms are glial heterotopia and nasal glioma, although the latter is a misnomer. The lesion mainly arises at the base of the nose or in the upper part of the nasal cavity, and grossly may be polypoid. Histologically, it is mostly composed of a mixture of astrocytes, glial fibres and fibrous connective tissue. Multinucleated glial cells are frequently found. Some glial cells can have large nuclei resembling nerve cells. Immunostaining for glial fibrillary acidic protein is a helpful diagnostic adjunct. A few true nerve cells or even ependymal elements can rarely be identified. Mitoses are not found.

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