G34 Failed Previous Grafts

Many corneal diseases can be treated by keratoplasty. Complications are rejection, formation of a retrocorneal fibrous membrane and recurrence of the original disease.

Rejection of the graft can occur immediately after the operation or many years later. Histologically, there is vascularisation of the corneal stroma, accompanied by a lymphocytic infiltrate.

Formation of retrocorneal fibrous membranes occurs following fibroblastic metaplasia of keratocytes at the posterior edges of the host-graft junction. This complication is diminishing with advances in microsurgery.

Over a longer period of time, recurrence of the original disease is common in patients with corneal dystrophies.

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