Extranodal Marginal Zone BCell Lymphoma of Mucosa Associated Lymphoid Tissue


Mucosa-associated lymphoid tissue (MALT lymphomas or immunocytoma in the REAL classification; small lymphocytic, lymphoplasmacytoid, diffuse small cleaved cell lymphoma in the Working Formulation) are low-grade extranodal lymphomas that comprise about 8% of all B-cell lymphomas, typically in gastrointestinal locations. Up to 14% occur in the head and neck area, but MALT lymphomas arising in Waldeyer's ring are exceptionally rare [112, 145]. In epithelial tissues, the MALT lymphoma cells infiltrate the epithelium, forming lympho-epithelial lesions. In Waldeyer's ring, however, caution is advised not to over-interpret the normally occurring intraepithelial lymphocytes within the tonsillar and nasopharyngeal mucosa as lymphoma [94]. In general MALT lymphomas run an indolent course with a tendency to remain localised. They are sensitive to radiation therapy. Patients have prolonged disease-free intervals after treatment, but recurrences may involve other extranodal sites.

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