Endothelial Dystrophies 103331 Fuchs Dystrophy

This disorder affects elderly patients and is quite common in routine histopathology. It presents clinically with bilateral diffuse cloudy and oedematous stroma. Histologically, the corneal epithelium is oedematous,

Descemet's membrane is thickened and there is reduction of the endothelial cell population. A PAS stain sometimes shows lamination of Descemet's membrane. On the posterior surface of Descemet's membrane, nodular excrescences can be seen.

the most extreme cases, causing bilateral blindness (ret-rolental fibroplasia). At the end stage of the disease neo-vascular glaucoma leads to enucleation. The distorted retina is macroscopically visible, most frequently forming a straight band behind the lens. Histology shows retinal gliosis and optic atrophy [21].

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