The maxillofacial skeleton is partly derived from migrated cranial neural crest cells. These cells give rise to most connective tissues in the craniofacial region including the bones of the calvarium, face and jaws. So, the diseases to be discussed in this chapter occur in bones that are formed by mesenchymal cells with an ectodermal/neuroectodermal ancestry - that is why they are also known as ectomesenchyme - and are therefore different from bone and cartilage that have a mesodermal origin elsewhere in the body [145, 171].

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