Conventional Squamous Cell Carcinoma

ICD-O:8070/3

Squamous cell carcinoma (SCC) is a malignant epithelial tumour with evidence of squamous differentiation such as intercellular bridges and keratin formation. It originates from the surface squamous epithelium, or from ciliated respiratory epithelium that has undergone squamous metaplasia [242].

Squamous cell carcinoma of the head and neck is the sixth most prevalent cancer worldwide, accounting for 5% of all new cancers, with a global annual incidence of 500,000 [42]. The vast majority of SCCs are the conventional type of SCC, accounting for more than 90% of cases. The remaining cases belong to the variants of SCC, which will be discussed later in this chapter.

Squamous cell carcinoma of the head and neck occurs most frequently in the oral cavity and lip, in the

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