Congenital Rubella Syndrome

Maternal rubella infection during the first trimester of pregnancy can affect the development and function of the entire eye. It can manifest as a congenital cataract,

Fig. 10.17. Cytomegaloviral retinitis: large eosinophilic inclusions are present in the infected endothelial cells. In this biopsy the retina showed almost no signs of necrosis, which is uncommon in cytomegalovirus retinitis

disciform keratitis, retinopathy, microphthalmus or open-angle glaucoma [3, 51]. In societies with immunisation the condition is rare. The histologic findings in the lens are characteristic, but it should be mentioned that the features may not yet be apparent in foetal eyes after early elective termination of pregnancy [38]. The central nucleus of the lens, which is normally free of cells, shows pyknotic nuclei. There is an abrupt transition from the central nucleus into the normal peripheral cortex of the lens [128].

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