Basaloid Squamous Cell Carcinoma


A basaloid squamous cell carcinoma (BSCC) is a poorly differentiated SCC composed of basaloid cells and squa-mous cell carcinoma, characterised by an aggressive clinical course. It was first described by Wain et al. in 1986 [372]. It has a predilection for the upper aerodigestive tract, but also occurs in other locations such as the uterine cervix [140], oesophagus [202], lung [51], and anus [90].

In the upper aerodigestive tract, BSCC shows a predilection for the hypopharynx (pyriform sinus), base of the tongue, and supraglottic larynx [195, 293]; it has also been described in the oropharynx [195, 293], oral cavity [69, 72, 159] and trachea [277, 312]. The suggested precursor of the BSCC is a totipotent primitive cell located in the basal cell layer of the surface epithelium, or within the seromucinous glands [293, 372].

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