Angioneurotic Oedema

Angioneurotic oedema, either acquired or hereditary, is characterised by sudden onset with full development within a few hours and fades over the course of 48-72 h. Gastrointestinal mucosa may also be affected, mainly in the hereditary disease, causing severe abdominal pain, nausea, vomiting and diarrhoea. Various degrees of laryngeal oedema may be present, affecting mainly the anterior surface of the epiglottis, aryepiglottic folds, base of the tongue and hypopharynx [238]. Generally, ANO resolves without harm, but laryngeal and tracheal oedema may cause asphyxiation and remains a considerable cause of death [90, 362]. The frequency of attacks in hereditary forms varies considerably from less than 1 to 25 per year. Lesions can be solitary or multiple, and primarily involve the extremities, larynx, face and bowel wall [90]. Emergency treatment is required if the process leads to respiratory distress because of laryngeal involvement.

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