Adenoid Cystic Carcinoma

ICD-O:8200/3

In contrast to other laryngeal carcinomas, adenoid cystic carcinoma (ACC) occurs at a younger age, with no gender predominance, and is more common in the subglottis [348]. Symptoms are similar to those of other tumours in the same localisation. In addition, pain is frequently present, probably because of the tendency of ACC towards perineural invasion.

Macroscopically, the tumour usually grows as a sub-mucosal mass, covered by normal mucosa.

The microscopic features of laryngeal ACC are the same as in other locations.

Laryngeal ACC is characterised by a slowly progressive course, with a high incidence of local recurrence, long survival and a low cure rate. ACC has a tendency towards haematogenic spread, mostly to the lungs and less frequently to the bones, liver and other organs [86, 348]. It does not usually metastasise to the regional lymph nodes.

The treatment of choice is complete surgical excision. The 5-year survival rate is 30% [221, 347].

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