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The balance of evidence suggests that dietary fats, particularly saturated fat, are likely to reduce insulin sensitivity but the effects of dietary carbohydrates on insulin sensitivity are more controversial.

The lipid-lowering effects of MUFAs compared to n-6 PUFAs are well studied, suggesting that MUFAs may be more potent at lowering plasma LDL-cholesterol and TG, whereas saturated fat increases LDL-cholesterol. There is concern that an intake above 55% from carbohydrate exaggerates the postprandial TG response.

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