Metabolic And Clinical Effects Of Alcohol Consumption

Alcohol Free Forever

Quit Drinking Alcohol

Get Instant Access

Evidence suggests that some of the clinical effects of alcohol ingestion are not due to ethanol itself but to its metabolites NADH and ethanal (acetaldehyde). The NAD + /NADH concentration ratio in the cytosol is maintained at a value of 1000 (11). The administration of alcohol can lower this ratio by at least 10fold (12). The concentration of all substrates and products which thus use dehydrogenase enzymes will be affected by a change in the NAD + /NADH concentration ratio. Therefore a reduction of this concentration ratio will lower the concentration of the oxidised reactant and increase that of the reduced reactant. If either of these reactants has an important metabolic role, marked changes in their concentration could produce abnormal effects.

The increased ethanal levels which are seen after alcohol ingestion are further raised if the activity of aldehyde dehydrogenase is inhibited. Inhibitors of the enzyme include the higher aliphatic aldehydes which are known to be present in alcoholic beverages.

The following physiological effects can be, in part, explained by the changes in the NAD + /NADH ratio.

Was this article helpful?

0 0
Booze Basher

Booze Basher

Get All The Support And Guidance You Need To Permanently STOP The Battle With Alcohol Once And For All. This Book Is One Of The Most Valuable Resources In The World When It Comes To Transformational Tools For Battling Booze Binges And Staying Alcohol-Free.

Get My Free Ebook

Post a comment