With the long experience in Bacillus proteomics, this expertise has been transferred to a closely related pathogenic gram-positive bacterium, Staphylococcus aureus. S. aureus is a human pathogen of increasing importance, mainly as a result of the spread of antibiotic resistance. The pathogenicity of this species is very complex and involves the strongly regulated production of cell-wall-associated and extracellular proteins forming a changing set of virulence factors. Due to the great variety of these proteins, S. aureus causes a broad spectrum of infectious diseases ranging from superficial abscesses to endocarditis, osteomyelitis, and toxic shock syndrome . Methicillin-resistant S. aureus (MRSA) strains are currently predominant and dangerous nosocomial pathogens, since infections caused by these strains have become difficult to treat. Vancomycin has become the drug of choice for treating MRSA infections. However, the emergence of vancomycin-resistant MRSA strains is leading to urgent demands for alternative anti-MRSA therapies and the development of totally new approaches to antibacterial drug research. This is the reason why the specialists are looking forward to the postgenome era heat stress oxidative stress t"
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