B. A. Dougherty, J. M. Merrick, et al. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496-512.

2 O'Farrell, P. H. 1975. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250:4007-4021.

3 Hecker, M. and U. Völker. 2004. Towards a comprehensive understanding ofBacillus subtilis cell physiology by physiological proteomics. Proteomics 4:3727-3750.

4 Hecker, M. 2003. A proteomic view of cell physiology of Bacillus subtilis -bringing the genome sequence to life. Adv. Biochem. Eng. Biotechnol. 83:5792.

5 Eymann, C., A. Dreisbach, D. Albrecht, J. Bernhardt, D. Becher, S. Gentner,

M. Hecker. 2004. A comprehensive pro-teome map of growing Bacillus subtilis cells. Proteomics 4:2849-2876.

6 Ludwig, H., G. Homuth, M. Schma-lisch, F. M. Dyka, M. Hecker, and

J. Stülke. 2001. Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon. Mol. Microbiol. 41:409-422.

J. Stülke, and M. Hecker. 1999. Role of CcpA in regulation of the central pathways ofcarbon catabolism in Bacillus subtilis. J. Bacteriol. 181:6996-7004.

8 Bernhardt, J., J. Weibezahn, C. Scharf, and M. Hecker. 2003. Bacillus subtilis during feast and famine: visualization of the overall regulation of protein synthesis during glucose starvation by proteome analysis. Genome Res. 13:224237.

9 Kock, H., U. Gerth, and M. Hecker. 2004. MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilis. Mol. Microbiol. 51:1087-1102.

10 Hecker, M. and U. Völker. 2001. General stress response of Bacillus subtilis and other bacteria. Adv. Microb. Physiol. 44:35-91.

11 Bernhardt, J., K. Büttner, C. Scharf,and M. Hecker. 1999. Dual channel imaging of two-dimensional electropherograms in Bacillus subtilis. Electrophoresis 20:2225-2240.

12 Hecker, M. and S. Engelmann. 2000. Proteomics, DNA arrays and the analysis of still unknown regulons and unknown proteins of Bacillus subtilis and pathogenic gram-positive bacteria. Int. J. Med. Microbiol. 290:123-134.

13 Drzewiecki, K., C. Eymann, G. Mitten-huber, and M. Hecker. 1998. The yvyD gene of Bacillus subtilis is under dual control of sigmaB and sigmaH. J. Bac-teriol. 180:6674-6680.

14 VanBogelen, R. A. 2003. Probing the molecular physiology of the microbial organism, Escherichia coli using proteomics. Adv. Biochem. Eng. Biotechnol. 83:27-55.

A. Ehrenreich, G. Gottschalk, J. Feesche, K. H. Maurer, and M. Hecker. 2004. A proteomic view of cell physiology of Bacillus licheniformis. Proteomics 4:1465-1490.

16 Leichert, L. I., C. Scharf, and M. Hecker. 2003. Global characterization of disulfide stress in Bacillus subtilis. J. Bacter-iol. 185:1967-1975.

G. Schiffer, S. Siegel, M. Bauser, J. Pohlmann, M. Brands, K. Ziegelbauer,

D. Haebich, C. Eymann, and H. Brötz-Oesterhelt. 2004. New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity. Antimicrob. Agents Che-mother. 48:525-532.

H. Labischinski, and M. Hecker. 2003. Proteomic approach to understanding antibiotic action. Antimicrob. Agents Chemother. 47:948-955.

19 Freiberg, C., H. Brötz-Oesterhelt, and H. Labischinski. 2004. The impact of transcriptome and proteome analyses on antibiotic drug discovery. Curr. Opin. Microbiol. 7:451-459.

20 Sender, U., J. Bandow, S. Engelmann, U. Lindequist, and M. Hecker. 2004. Proteomic signatures for daunomycin and adriamycin in Bacillus subtilis. Pharmazie 59:65-70.

21 Crossley, K. B. and Archer L. A. 1997. The staphylococci in human disease. Churchill Livingstone, New York.

22 Chan, P. F., R. Macarron, D. J. Payne, M. Zalacain, and D. J. Holmes. 2002. Novel antibacterials: a genomic approach to drug discovery. Curr. Drug Targets Infect. Disord. 2:291-308.

23 Blondelle, S. E. and R. A. Houghten. 1996. Novel antimicrobial compounds identified using synthetic combinatorial library technology. Trends Biotechnol. 14:60-65.

24 Rachakonda, S. and L. Cartee. 2004. Challenges in antimicrobial drug discovery and the potential ofnucleoside antibiotics. Curr. Med. Chem. 11:775793.

T. Baba, H. Yuzawa, I. Kobayashi, L. Cui, A. Oguchi, K. Aoki, Y. Nagai, J. Lian, T. Ito, M. Kanamori, H. Matsumaru, A. Maruyama, H. Murakami, A. Hos-oyama, Y. Mizutani-Ui, N. K. Takahashi, T. Sawano, R. Inoue, C. Kaito, K. Seki-mizu, H. Hirakawa, S. Kuhara, S. Goto, J. Yabuzaki, M. Kanehisa, A. Yamashita, K. Oshima, K. Furuya, C. Yoshino, T. Shiba, M. Hattori, N. Ogasawara, H. Hayashi, and K. Hiramatsu. 2001. Whole genome sequencing of meticil-lin-resistant Staphylococcus aureus. Lancet 357:1225-1240.

26 Cordwell, S. J., M. R. Larsen, R. T. Cole, and B. J. Walsh. 2002. Comparative proteomics of Staphylococcus aureus and the response of methicillin-resistant and methicillin-sensitive strains to Triton X-100. Microbiology 148:2765-2781.

27 Kohler, C., C. von Eiff,G. Peters, R. A. Proctor, M. Hecker, and S. Engelmann. 2003. Physiological characterization of a heme-deficient mutant of Staphylococcus aureus by a proteomic approach. J. Bac-teriol. 185:6928-6937.

28 Scherl, A., P. Francois, M. Bento, J. M. Deshusses, Y. Charbonnier, V. Conver-set, A. Huyghe, N. Walter, C. Hoogland, R. D. Appel, J. C. Sanchez, C. G. Zim-mermann-Ivol, G. L. Corthals, D. F. Hochstrasser, and J. Schrenzel. 2005. Correlation of proteomic and transcrip-tomic profiles of Staphylococcus aureus during the post-exponential phase of growth. J. Microbiol. Methods 60:247257.

29 Ohta, T., K. Honda, M. Kuroda, K. Saito, and H. Hayashi. 1993. Molecular characterization of the gene operon of heat shock proteins HSP60 and HSP10 in methicillin-resistant Staphylococcus aureus. Biochem. Biophys. Res. Commun. 193:730-737.

30 Chastanet, A., J. Fert, and T. Msadek. 2003. Comparative genomics reveal novel heat shock regulatory mechanisms in Staphylococcus aureus and other Gram-positive bacteria. Mol. Microbiol. 47:1061-1073.

31 Weber, H., S. Engelmann, D. Becher, and M. Hecker. 2004. Oxidative stress triggers thiol oxidation in the glyceralde-hyde-3-phosphate dehydrogenase of Staphylococcus aureus. Mol. Microbiol. 52:133-140.

32 Singh, V. K., R. K. Jayaswal, and B. J. Wilkinson. 2001. Cell wall-active antibiotic induced proteins of Staphylococcus aureus identified using a proteomic approach. FEMS Microbiol. Lett. 199:79-84.

33 Nakano, M. M., P. Zuber, P. Glaser, A. Danchin, and F. M. Hulett. 1996. Two-component regulatory proteins ResD-ResE are required for transcrip-tional activation of fnr upon oxygen limitation in Bacillus subtilis. J. Bacteriol. 178:3796-3802.

34 Throup, J. P., F. Zappacosta, R. D. Luns-ford, R. S. Annan, S. A. Carr, J. T. Lons-dale, A. P. Bryant, D. McDevitt,

M. Rosenberg, and M. K. Burnham. 2001. The srhSR gene pair from Staphy-lococcus aureus: genomic and proteomic approaches to the identification and characterization of gene function. Biochemistry 40:10392-10401.

35 Hecker, M., S. Engelmann, and S. J. Cordwell. 2003. Proteomics of Staphylococcus aureus - current state and future challenges. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 787:179-195.

36 Bischoff, M., P. Dunman, J. Kormanec, D. Macapagal, E. Murphy, W. Mounts, B. Berger-Bächi, and S. Projan. 2004. Microarray-based analysis of the Staphylococcus aureus sigmaB regulon. J. Bac-teriol. 186:4085-4099.

37 Gertz, S., S. Engelmann, R. Schmid, A. K. Ziebandt, K. Tischer, C. Scharf,

J. Hacker, and M. Hecker. 2000. Characterization of the sigma(B) regulon in Staphylococcus aureus. J. Bacteriol. 182:6983-6991.

38 Ziebandt, A. K., H. Weber, J. Rudolph, R. Schmid, D. Höper, S. Engelmann, and M. Hecker. 2001. Extracellular proteins of Staphylococcus aureus and the role of SarA and sigma B. Proteomics 1:480-493.

39 Ziebandt, A. K., D. Becher, K. Ohlsen, J. Hacker, M. Hecker, and S. Engelmann. 2004. The influence of agr and sigma(B) in growth phase dependent regulation of virulence factors in Staphy-lococcus aureus. Proteomics 4:30343047.

E. L. Brown, R. J. Zagursky, D. Shlaes, and S. J. Projan. 2001. Transcription profiling-based identification of Staphy-lococcus aureus genes regulated by the agr and/or sarA loci. J. Bacteriol. 183:7341-7353.

41 Novick, R. P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Micro-biol. 48:1429-1449.

H. E. Meyer, R. Kurzbauer, L. A. Huber, and C. S. Klade. 2002. Identification of vaccine candidate antigens of Staphylococcus aureus by serological proteome analysis. Proteomics 2:580-590.

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