Nmb0065

ctrA ctrB ctrCctrD

y/galErfbB' rfbA'rfbC'

litC rfbA rfbB galE

oatC siaDc siaC siaB siaA tex vdcmhk'damH iipA UpB

rfbC rfbA rfbB gaiE tex dcmH damH

ribC rfbA rfbB galE tex tex

NmCFAM1S

Ng FA109Q Nl DSM4691 Ns LMG5290

Fig. 11.3 Comparison ofthe cps locus of pathogenic and apathogenic Neisseria species. Regions with identical functions are depicted in the same colors. The following sequence data were used to compare the cps loci: NmB B1940: assembled from the GenBank sequences L09188, L09189, M57677, M95053, and Z13995; NmB MC58: AE002098; NmA Z2491: AL157959; NmC FAM18: NC_003221, homologous genes according to BLASTX [75] searches against the annotated neisserial genomes; Ng FA1090: AE004969; Nl DSM4691 and

Ns LMG5290: H. Claus and U. Vogel, unpublished data. The gene assignment of the meningococcal sequences was done following the annotation ofthe MC58 genome. Ng, N. gonorrhoeae; Nl, N.lactamica; Nm, N. meningitidis; Ns, N. sicca; DSM, German type culture collection (Deutsche Sammlung von Mikroorganismen), Braunschweig, Germany; LMG, Belgian collection of microorganisms (Laboratorium voor Microbiologie, University ofGent), Gent, Belgium. (This figure also appears with the color plates.)

be a result of successive imports, deletions, and rearrangements [86]. Interestingly, in strain B1940 the DNA fragment comprising regions D' through D exhibits an inverse orientation compared to the other meningococcal cps sequences. This inversion was also observed in strains belonging to the same sequence type, indicating a high frequency of inversion in vivo (H.Claus et al. 2001, unpublished).

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