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Novel Virulence Factors of Meningococci Identified by Genomic Approaches

Besides the capsular polysaccharide of meningococci, many virulence factors were identified in gonococci and meningococci in the pregenomic era. Table 11.2 shows a selection of well-studied virulence factors in the pathogenic Neisseria species.

Table 11.2 Presence of virulence genes in the four sequenced genomes of pathogenic Neisseria spp. as identified byTBLASTN [75] searches'3'.

Virulence gene N. gonorrhoeae N. meningitidis

Serogroup A Serogroup B Serogroup C

Strain FA1090 Strain Z2491 Strain MC58 Strain FAM18

LOS sialylation lst

Table 11.2 Continued.

Virulence gene

N. gonorrhoeae

N. meningitidis

Strain FA1090

Serogroup A Strain Z2491

Serogroup B Strain MC58

Serogroup C Strain FAM18

Capsule expression ctrA

ctrB

ctrC

ctrD

lipA

lipB

mynA[c]

mynB[c]

mynC[c]

mynD[c]

siaA

siaB

siaC

siaD

Type IV pilus proteins pilC1/pilC2

pilE

pilM

pilN

pilO

pilP

pilQ

Virulence gene

N. gonorrhoeae

N. meningitidis

Serogroup A Serogroup B Serogroup C Strain Z2491 Strain MC58 Strain FAM18

Strain FA1090

Adhesins

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