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Fig. 22.1 Section of an E. coli pathoarray. (a) Composition of target genes spotted on the glass slide. White boxes refer to virulence genes of extraintestinal pathogenic E. coli (ExPEC), light gray boxes represent genes of intestinal pathogenic E. coli (controls); further internal controls are given in dark gray boxes. (b) The results of a hybridization experiment with genomic DNA of a uropathogenic E. coli isolate; light dots represent strong hybridization signals.

Table22.2 Target genes represented on an E. coli "pathoarray".

Target / Gene Accession no. Gene product source

Toxins

CdtB-III U893G5

Cnf1 AE483829

Cnf2 UG1G97

EHEC-HlyA X79839 UPEC-HlyA

East1-2 AE411G67

Cytolethal distending toxin-IIIB. Induces cell growth arrest and apoptosis Cytotoxic necrotizing factor 1. Induces reorganization of actin cytoskeleton Cytotoxic necrotizing factor 2. Induces reorganization of actin cytoskeleton Hemolysin toxin protein of enterohemorrhagic E. coli

Hemolysin toxin protein of uropathogenic E. coli Heat-stable enterotoxin 1

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