446 | 20 Model Host Systems: Tools for Comprehensive Analysis of Host-Pathogen Interactions tions aimed at human-related traits (Fig. 20.1). Important prerequisites for model systems in general are a short life cycle with rapid development, small size, inexpensive availability, and tractability to molecular and genetic tools [1]. In recent years a large body of information has been derived from model organisms. The insights include behavior, immunity, aging, inheritance, physiology, development, cellular processes, cancer, and neurodegenerative and other diseases. Studies of the genomic organization of widely divergent model organisms have revealed a remarkable degree of evolutionary conservation and enabled meaningful cross-species comparisons. In addition, interactions between organisms have been studied. These interactions range on a continuous scale from symbioses to pathogen-esis. Here we want to focus on host-pathogen interactions.

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