Conclusions

We show here that many predictions about pathogens are possible on the basis of sequence and other data by applying bioinformatic tools, including analysis of gene expression data and software designed to reveal pathogen-specific features. However, bioinformatics provides only a valuable start as it rapidly identifies potential new targets (including subtle structural differences), new leads, or further cellular processes to consider. Subsequent further development and validation of leads and targets is done in close collaboration with experimental researchers.

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