Classical Genetics Still at the Forefront in the Postgenome

Classically, the most popular and successful approaches for identifying microbial virulence determinants have been directed and random mutagenesis [3]. Despite their apparent lack of "hype" compared to the genome-scale functional approaches presented later, these methods have all but disappeared with the advent of the genomic era. On the contrary, both approaches have been greatly facilitated by the availability of complete genomic sequences and will undoubtedly remain important tools for determining gene function.

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