We would like to thank the many of our colleagues who have contributed in different ways to this research, in particular P. Glaser for his constant support, his critical view of the results and many fruitful discussions; F. Kunst for his important help and support; and C. Rusniok for his help and never-ending patience with informatics problems or questions. This work received financial support from the Institut Pasteur, the Centre National de la Recherche, and from the Consortium National de Recherche en Génomique du Réseau National des Genopoles, France. C. Cazalet is holder of a fellowship jointly financed by the Centre National de la Recherche, France and VeoliaWater - Anjou Recherche.

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