Quality Control and Laboratory Issues

The advantages and disadvantages of the competing assays are discussed above. The widespread use of both the IHC and FISH techniques in clinical laboratories to assess HER2/NEU status in breast cancer has been the subject of many reviews as to performance and quality-control issues.70,71 The College of American Pathologists has a proficiency-testing program that allows participating laboratories to assess their performance compared to a wide variety of private, public, and commercial laboratories.

TP53

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