Molecular Basis of Disease

There are two broad genetic changes that can be studied in T-cell lymphomas, namely, T-cell receptor (TCR) gene rearrangements and chromosomal translocations, deletions, or additions.

and mycosis fungoides. Related neoplasms of natural killer (NK) cells also occur, but because these are not true T-cell-derived tumors, they do not usually demonstrate T-cell receptor gene rearrangements. The T- and NK-cell neoplasms of the World Health Organization (WHO) classification are listed in Table 33-1.3

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