Molecular Basis of Disease

The molecular basis of AML is to some extent dependent on the age of the population under consideration. In children and younger adults, balanced chromosomal translocations are relatively common, while in older patients AML is characterized by a more common picture of chromosomal losses and gains, often in the context of a complex karyotype. Evidence to date suggests that karyotype identifies biologically distinct subsets of disease and is highly predictive of response to therapy and overall survival (reviewed in Reference 1).

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