Laboratory Issues

For a discussion applicable to laboratory issues for HB, see the "Laboratory Issues" section for HA.

VON WILLEBRAND DISEASE

Von Willebrand disease (VWD) is an autosomal disorder characterized by a deficiency of von Willebrand Factor (VWF) and is the most commonly recognized congenital bleeding disorder, with a prevalence varying from 0.82% to 2%.14 Diagnosis is established based on a personal and family history of abnormal clinical bleeding and reduced plasma VWF antigen levels or functional activity (risto-cetin cofactor activity) or both, and analysis of size distribution of the VWF multimers.

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