Laboratory Issues

The FISH test is performed by cytogenetics laboratories, which routinely process cultured cells. Probes for WS testing are commercially available (sources include Cytocell, Inc, and Vysis, Inc). These probe sets are classified by the US Food and Drug Administration (FDA) as analyte specific reagents. Recommendations for test validation methods have been established by the ACMG (http://www.acmg. net/). Proficiency testing for FISH analysis of microdeletion disorders, such as WS, is available through the CAP.

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