EGFR is overexpressed in 14% to 90% of breast cancers, depending on the material tested and the method used for detection or quantitation of the receptor. EGFR overexpression has been linked to adverse prognosis in a variety of tumors, including breast cancer.3,4 Conflicting studies of EGFR status in breast cancer have been reported, with some groups finding a correlation with prognosis5 and others finding no correlation.6 The frequent finding of gene amplification, gene mutation, or protein overexpression of EGFR, or some combination of these, in breast cancer, which has ranged from 67% to as high as 90% of breast cancers,7 has prompted numerous clinical trials employing small molecule inhibitors8 and antibodies9 that target the EGFR pathway. To date, the clinical trials have yielded some evidence of efficacy, and one agent (ZD1839, Iressa) has been FDA approved for use in lung cancer. EGFR-targeted therapies have not moved forward for the treatment of breast cancer. In addition, levels of
EGFR expression have not correlated with therapeutic outcome.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.