Clinical Significance

In general, breast carcinomas with TP53 mutations are consistently associated with high histologic grade, high mitotic index, high proliferation rate, aneuploid DNA content, negative assays for ER/PR,76-78 and variable association with amplification of oncogenes such as HER2, MYC, RAS, and INT2.79,80 TP53 mutation has been correlated with resistance to hormonal, adjuvant, and neoadjuvant chemotherapy and combination chemotherapy for metastatic disease using a variety of agents, including anthracyclines and taxanes.81-84

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