Chronology

1936 William French Anderson born in Tulsa, Oklahoma, on

December 31

1936 William French Anderson born in Tulsa, Oklahoma, on

December 31

1963

Anderson earns medical degree from Harvard University

1965

Anderson joins Marshall Nirenberg's laboratory at National

Institutes of Health and helps to decipher the genetic code

1968

Anderson begins work on thalassemia

1974

Anderson ends work on thalassemia because it is not leading

to gene therapy

1984

Richard Mulligan invents a way to make retroviruses safe to

use as vectors for carrying genes

Anderson and Michael Blaese begin plans to treat ADA

deficiency with gene therapy

1987

Don Kohn invents a way to put the ADA gene into white cells

RAC rejects Anderson group's first proposal to perform gene

therapy

PEG-ADA, a drug to treat ADA deficiency, is created

1988 Anderson, Blaese, and Steven Rosenberg plan to use an added gene as marker in an experimental cancer treatment

1989 On May 22, Rosenberg group inserts foreign genes into human beings for the first time

1990 In the summer, RAC grants approval for Anderson's group to use gene therapy on a single ADA-deficient child

The parents of the child, Ashanthi DeSilva, consent to the treatment

On September 14, Anderson places genetically altered cells into DeSilva, providing the first approved use of gene therapy to treat disease

1992 French Anderson moves from National Institutes of Health to

University of Southern California (Los Angeles)

Ashanthi DeSilva's gene treatments end in August

1999 Jesse Gelsinger dies on September 17 as a result of experimen tal gene therapy

2002 Two children in France, seemingly cured of an immune system disorder by gene therapy, develop leukemia

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