Knops Blood Group System Facts Sheet

ISBT Gene Name: Organization:

Chromosome: Gene product:

39 exons distributed over 140 kbp in A allele (variant form exists with 8 extra exons)

lq32

Complement receptor type 1 (CR1; CD35) (1,998 amino acids)

GenBank Accession: Y00816, X05309; X14893

STOP

h 1 kbp

Figure 4.32 KN gene.

Alleles: KN 1/KN 2 and 3 variants

Antigens: Kna/Knb, McCa, Sl\ Yka

Prevalence of gene products (% based on phenotyping):

Phenotype

Caucasians

Blacks

Kn(a-t-b-)

94.5

99.9

Kn(a-b+)

1

0

Kn(a+b+)

4.5

0.1

McC(a+)

98

94

Sla(a+)

98

60

Yka(a+)

92

The molecular basis of these antigens has not been determined.

References

Ahearn, J.M. and Fearon, D.T. (1989) Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv Immunol 46, 183-219.

Klickstein, L.B., Wong, W.W., Smith, J.A., et al (1987) Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins. J Exp Med 165,1095-1112.

Vik, D.P. and Wong, W.W. (1993) Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele. J Immunol 151, 6214-6224.

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