Knops Blood Group System Facts Sheet

39 exons distributed over 140 kbp in A allele (variant form exists with 8 extra exons) Complement receptor type 1 (CR1 CD35) (1,998 amino acids) GenBank Accession Y00816, X05309 X14893 Alleles KN 1 KN 2 and 3 variants Antigens Kna Knb, McCa, Sl Yka Prevalence of gene products ( based on phenotyping) The molecular basis of these antigens has not been determined. Ahearn, J.M. and Fearon, D.T. (1989) Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv Immunol 46,...

Marion E Reid PhD

Head, Immunochemistry Laboratory New York Blood Center, New York A Harcourt Science and Technology Company San Diego San Francisco New York Boston London Sydney Tokyo This book is printed on acid-free paper. Copyright 2000 by ACADEMIC PRESS All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from...

Principle

Variable number of tandem repeat (VNTR) and short tandem repeat (STR) sequences are inherited repeating stretches of DNA from hundreds (VNTRs) to a few (STRs) nucleotides generally found in the non-coding regions of the human genome. These stretches of DNA show size heterogeneity among humans and are inherited in a co-dominant fashion. In the test, oligonucleotide primers, flanking a VNTR STR, are extended using the PCR. Agarose or polyacrylamide gel electrophoresis is used to estimate the PCR...

Red Cell Blood Groups

The terminology used for antigens is that recommended by the Working Party on Terminology for Red Cell Surface Antigens of the International Society of Blood Transfusion ISBT Daniels et al 1995, 1996, 1999 . This Working Party has categorized over 250 different blood group antigens Into Systems, Collections, Low Incidence Antigens, and High Incidence Antigens. The terminology is inconsistent. A single letter e.g., A, D, K , a symbol and a superscript e.g., Fy'1, Fyb, JkJ , and a numerical...